If nefroni gradually die, the body accumulates nitrogen metabolism end products and develops chronic renal failure. These types of renal failure can cause any chronic progressive renal disease (chronic glomerulonephritis, interstitial nephritis, vascular nephropathy, renal congenital anomaly) as well as some metabolic diseases (such as diabetes), connective tissue sistēmslimības (disseminated lupus erythematosus), which are characterized by renal failure , hypertensive disease (primarily contracted kidney). Functioning nefronu Number of becoming less, so 1) reduced glomerular filtration volume, 2) worsening secernējamo and reabsorbējamo substance transport, resulting in a reduction of renal concentration capacity, 3) is disturbed electrolyte balance in the body.Chronic renal failure are distinguished four stages:Stage I or full compensation step (function over V3 from all nefroniem)Stage II or stage of compensated retention,Stage III or stage of decompensation,Stage IV or terminal renal failure.Chronic renal failure patients live for several years, until they illnesses. It is characterized by irreversible, progressive accumulation of a metabolite and highly homeostasis disorders in the body.Chronic renal insufficiency mechanism is functioning nefronu number and renal concentration capacity reduction. Stage renal failure compensation will continue until the urine filtration is still 35-50% of the normal filtration. Impaired renal concentration ability (urine specific gravity of less than 1,020) offset forced polyuria. Urine filtration, reabsorption and daily diuresis is normal clinical renal failure with no symptoms.Chronic renal failure, II, or compensated retention stage occurs when urine filtration is no longer limited to 25-35% of normal.
